Profhilo is an injectable product in the hyaluronic acid (HA) family, made of high and low molecular weight HA in the form of stable hybrid cooperative complexes, produced through the NAHYCO® thermal process without chemical cross-linking. Its primary purpose is to increase hydration and improve tissue condition or skin quality (bio-remodeling), rather than sculpting shape or adding localised volume like a structural filler.
When injected appropriately, results tend to be gradual — skin looks more hydrated, smoother, more elastic, and firmer — and you should not expect it to lift significantly sagging skin, fill deep folds, or reshape the face as much as procedures designed specifically for those goals.
The information in this article is for general education only and is not a diagnosis or individual advice. Results vary from person to person. You should be assessed by a doctor before making a decision.
Profhilo โปรแกรม Bio-remodeling ด้วยไฮยาลูรอนิกแอซิด
What is Profhilo made of, and how is it different from ordinary HA?
The product insert states that a 2 mL syringe of Profhilo contains 64 mg of sodium hyaluronate in total — 32 mg high molecular weight HA and 32 mg low molecular weight HA — in a buffer solution. NAHYCO® technology uses a thermal process to make both molecular chains form hybrid complexes without chemical cross-linking modification.
Its flow and spreading properties allow the doctor to place the product at planned points and let it distribute over a wider area than shape-retaining gels. However, "spreads well" does not mean it can be injected anywhere. The choice of injection plane, points, volume, and patient still requires anatomical knowledge and individual assessment.
What does Profhilo help with? Reasonable expected results
กลไกการทำงานของ Profhilo ในชั้นผิวและ extracellular matrix
Current clinical evidence supports that HA hybrid cooperative complex products may improve some skin parameters, including hydration, elasticity, firmness, smoothness, and mild-to-moderate laxity.
- Increases skin hydration and water content, making skin look brighter and smoother
- Supports elasticity, firmness, and overall skin quality
- Helps soften shallow lines related to dryness or thin skin
- Helps with mild-to-moderate laxity in well-selected cases
- Gives fairly natural results, because it does not aim to create volume bumps or sculpt specific proportions
What Profhilo does not do directly: it does not stop muscle activity like botulinum toxin; it does not build up the bony base or create chin, nose, or facial framework like a structural filler; and it does not replace surgery or energy-based lifting devices in cases of significant sagging.
Who is Profhilo suitable for?
บริเวณที่เหมาะกับ Profhilo ใบหน้า คอ เนินอก แขน และมือ
Profhilo may suit adults who are starting to notice dry skin, loss of elasticity, thin-looking skin, tiredness, or mild sagging, and who want natural results without emphasis on adding shape. Areas commonly assessed include the face, neck, décolletage, arms, and hands.
Who should delay or avoid it?
- Pregnant or breastfeeding — generally postpone, as safety data in this group is insufficient
- Infection, inflamed rash, wound, or a herpes flare-up in the area to be injected
- Previous allergy to hyaluronic acid or product components
- Autoimmune disease, bleeding disorders, or use of medications affecting blood clotting — do not stop medication yourself; consult your treating doctor
- Planning laser resurfacing or a medium-to-deep chemical peel in the same period — spacing must be planned
What are the steps of a Profhilo treatment?
ขั้นตอนการทำ Profhilo และการประเมินโดยแพทย์
- Take a history of health, medications, supplements, allergies, previous procedures, and desired goals
- Assess skin condition, degree of sagging, facial structure, and consider whether the problem comes from skin, fat, ligaments, muscle, or bone
- Explain options, expected results, limitations, costs, risks, and a plan for managing complications before signing consent
- Clean the skin and inject with appropriate technique under aseptic principles
- Record the product name, volume, lot number, expiry date, injection points, and give aftercare advice with contact channels
The BAP (Bio Aesthetic Points) technique on the face commonly refers to 5 points per side, using 0.2 mL per point, totalling 2 mL per session as per the original product insert. The doctor may adjust according to facial morphology and current indications.
Does Profhilo hurt? How many days of downtime? When do the bumps settle?
The sensation is usually a temporary sting, burning, or tightness at the injection site. The level of pain depends on the location, technique, and the individual. After injection you may see small raised bumps, redness, swelling, or bruising. Recent reviews report that common adverse effects are usually mild and typically resolve within about 72 hours, while in some cases bumps settle within a few hours to 1-3 days.
Do not wait if there are danger signs: severe or increasing pain, pale or mottled purple skin, cold skin, blisters, vision changes, eye pain, unusual headache, increasing facial swelling after several days, fever, pus, or a whole-body allergic reaction — contact a doctor or emergency services immediately, because vascular occlusion is rare but a serious complication of HA injection.
How many days to see results? How many sessions?
| Timeframe | What you may notice | Good to know |
|---|---|---|
| Day 1-3 | Swelling, bumps, redness or bruising from injection | Not yet a picture of the final result |
| 1-4 weeks | Hydration and plumper-looking skin gradually become clearer | Results vary and are affected by skincare or concurrent swelling |
| Around week 4 | Second session per the initial protocol | The insert recommends 2 sessions, 30 days apart |
| 8-12 weeks | Assess texture, firmness, elasticity after the full course | Studies in Asian populations follow up to week 12 |
| After that | Plan maintenance according to skin, age, goals | There is no single interval that suits everyone |
A straightforward way to communicate this is: "Generally start with 2 sessions about 1 month apart, and assess results after the full course." You should not guarantee that one session gives the same result for everyone.
Does Profhilo last long?
The effects of HA and changes in skin quality are temporary. The observable duration depends on skin, age, sun behaviour, smoking, weight, underlying conditions, technique, and the criteria used to measure it. Many clinics communicate that results may last around several months or about 6 months, but this should not be used as a guarantee. It is better to take standardised photos and assess before repeating, rather than injecting on a calendar schedule without checking necessity.
How is Profhilo different from fillers and skin boosters?
| Procedure | Main goal | Not the main choice when |
|---|---|---|
| Profhilo | Bio-remodeling and skin quality — diffuse hydration, elasticity, firmness | You want to sculpt the chin or nose, or fill the bony base or deep folds |
| HA Filler | Add volume, provide support, reshape | You only want overall skin hydration without adding shape |
| Skin Booster | Injection to improve skin quality; many formulas and techniques | You want a structural result or significant lift of sagging |
| Botulinum toxin | Reduce muscle contraction | The main problem is dry skin or elasticity |
| RF or HIFU | Energy-based lifting, tissue stimulation | You want to add volume or directly treat dehydration |
The phrase "Profhilo is not a filler" should be explained precisely: it is not used as a dermal filler to build framework or localised volume as its main role, but the product insert also contains wording about a corrective or filling action. So it is better to say "not primarily a shaping filler."
How is Profhilo different from PN, PLLA, PCL, Sculptra, Radiesse, and HarmonyCa?
| Group | Substance or brief mechanism | Suited to the goal of |
|---|---|---|
| Profhilo | HA hybrid complexes | Hydration, elasticity, skin quality |
| PN / Polynucleotide | Polynucleotide chains; focus on the skin-repair environment | Thin, easily irritated skin; texture or under-eye in some products |
| PLLA / Sculptra | Poly-L-lactic acid particles that stimulate collagen | Gradual structure and volume |
| PCL | Polycaprolactone that supports and stimulates collagen | Cases needing support and longer duration than some HA |
| CaHA / Radiesse | Calcium hydroxylapatite in a carrier gel | Structural support and biostimulation |
| HarmonyCa | Hybrid cross-linked HA + CaHA | Volume or support combined with collagen stimulation |
None is "the best" without specifying the problem. If skin is dry and starting to sag mildly, Profhilo may be on target. If there is clear volume loss, you may need a filler or biostimulator. If lines come from muscle, you may need botulinum toxin.
Preparation and aftercare
การดูแลผิวหลังทำ Profhilo
Before treatment: disclose underlying conditions, allergies, herpes, a history of lumps or inflammation from injectables, and all previous procedures. Bring a list of all medications and supplements for the doctor to review, especially anticoagulants and immunosuppressants. Do not stop doctor-prescribed medication yourself. Postpone if you have a fever, are unwell, or have inflamed acne, a wound, a rash, or an infection in the area to be injected.
After treatment:
- Do not press, massage, or rub the injection area yourself unless advised by the treating doctor
- Keep the area clean and avoid make-up until the needle points close
- Avoid sun and UV and use strict sun protection for at least 3-5 days
- Avoid strenuous exercise, intense heat, sauna, and alcohol during the first 24 hours
- If bruising occurs, apply gentle cold compresses without hard pressure, and avoid self-medicating
- Keep the clinic's contact number and report any abnormal symptoms immediately, without waiting for the follow-up appointment
How much does Profhilo cost?
The price depends on the clinic, volume, area, number of syringes, doctor assessment fee, and promotions. From publicly disclosed price pages in Bangkok around mid-2026, example prices of about THB 19,500-35,000 per 2 mL syringe were seen, but this is only a market snapshot at one point in time, not a standard price. When comparing prices, ask clearly which version of Profhilo it is, how many mL, price per session or for the whole course, whether it includes assessment, anaesthetic and follow-up, and whether the box can be opened and the lot number recorded in front of you.
How to check authenticity before injection
- Have it done at a licensed medical facility with a doctor assessing and performing it
- Ask to see the box, Thai-language label, registration number, lot number, and expiry date before opening
- Check the product name or registration number through Thai FDA channels
- Have the clinic record the product name, volume, lot number, and injection points in the medical record
- Avoid buying the product to inject yourself, sharing a syringe between people, or services outside a medical facility
Frequently asked questions about Profhilo
Is Profhilo a filler?
Not primarily a shaping filler or one that adds localised volume. Its purpose is bio-remodeling and skin quality. However, because it is an injectable HA, it still has the physical properties and risks of an HA injection procedure that must be explained fully.
Does Profhilo make the face bigger or cause permanent swelling?
It should not be designed to make the face bigger. Temporary swelling and bumps may occur after injection. If swelling increases, lasts longer than expected, or there is asymmetry, return to the doctor for assessment. Do not massage or inject a dissolving agent yourself.
Does Profhilo help acne scars?
The product insert mentions scars from superficial injury, such as acne marks, but evidence specifically on acne scars is not strong enough to consider it a primary treatment. Different types of acne scars may need subcision, laser, microneedling, TCA CROSS, or filler depending on assessment.
How many CC of Profhilo is used?
The formulation discussed is 1 syringe = 2 mL, and the full-face BAP protocol commonly uses a total of 2 mL per session. But the actual volume and locations depend on the product version, indications, and the doctor.
Can Profhilo be done in a single session?
It can be done in some plans, but the commonly used initial protocol stated in the IFU is 2 sessions, 30 days apart. A single session may not give the same result as the full course.
Can Profhilo be done together with filler, botulinum toxin, or lifting devices?
They may be planned together because they address different layers, but the sequence, locations, and spacing must be set by the doctor. The product insert states it should not be used at the same time as laser resurfacing and medium-deep peel.
What age is Profhilo suitable for?
There is no single age that suits everyone. Choose based on skin condition, degree of sagging, goals, health, and value for money. Do not do it simply because you have reached an age set by advertising.
Summary
Profhilo is an option for those who want to restore hydration, elasticity, firmness, and smoothness of the skin gradually and naturally. Its strength is the bio-remodeling concept using high and low molecular weight HA stabilised without chemical cross-linking. But its results have limits and do not replace filler, botulinum toxin, energy devices, or surgery when the problem is in a different layer.
Consult a doctor at Orianna Clinic to assess whether Profhilo suits your skin concerns before planning individual treatment.
Orianna Clinic "Beauty in your own"