VITARAN is an injectable product in the polynucleotide, or PN, group, which focuses on improving skin quality rather than adding volume or changing face shape. The strength of the PN approach is caring for skin that is thin, dry, lacking elasticity, has fine lines, or needs gradual restoration. The doctor chooses the formula, dose, skin layer, technique, and number of sessions to suit each area and each individual.
Clinical evidence for PN in aesthetic medicine is growing, but is not yet equal across every area. A notable randomised study found benefits for periocular skin quality compared with non-crosslinked hyaluronic acid, while evidence supporting use in other areas varies in level.
The information in this article is provided for general education only, does not guarantee results, does not set a fixed treatment formula, and does not replace an assessment by a doctor.
VITARAN โปรแกรม PN สำหรับฟื้นฟูคุณภาพผิว
What are VITARAN and PN?
PN stands for polynucleotide, a chain of nucleotides that has been purified and prepared as a medical product. VITARAN products sold in various markets state a PN concentration of 20 mg/mL, but the formula name, packaging size, indication, and registration status may differ by country and batch. Clinics should therefore check the label, product documentation, and the actual registration number used in Thailand before treatment.
In terms of communication, the phrase "cellular-level regeneration" should be used cautiously, as it is marketing language that can be interpreted beyond the evidence. More accurate phrases include "supports the restoration of skin quality," "helps skin look smoother and more elastic," and "results vary from person to person."
| Approach | Main goal | What should not be expected |
|---|---|---|
| PN, such as VITARAN | Skin quality and elasticity | Not building structure or filling deep folds immediately |
| HA filler | Volume and structure | Not the main answer for every case of thin skin |
| Botulinum toxin | Reduces muscle force | Does not add volume and does not restore skin directly |
| Energy device | Contracts and remodels collagen structure with energy | Does not replace adding volume or fixing localised thin skin |
Who may be suitable for VITARAN
บริเวณที่ VITARAN อาจเหมาะ ใต้ตา แก้ม รอบปาก คอ
- Those concerned about thin, dry, periocular skin with fine lines or a tired look, without under-eye bags or deep hollows as the main problem
- Those with dry, rough facial skin, uneven texture, reduced elasticity, or visible pores
- Those who want gradual skin-quality results and accept that this usually requires a course of treatments as assessed by a doctor
- Those with thin, wrinkled skin on the neck, décolletage, back of the hands, or other areas, with suitability assessed per area
Who should avoid or postpone treatment: pregnant or breastfeeding · has an infection, wound, severe acne inflammation, or an active rash at the injection site · has a history of allergy to the product's components, especially those with a severe fish-allergy history, who should inform the doctor · has an autoimmune condition, a bleeding disorder, uses anticoagulant medication, or has a history of keloids · expects filling of deep folds, a facelift, or a clearly changed face shape from PN alone.
Which areas can VITARAN be used on?
The word "every area" does not mean the same formula, dose, or layer can be injected throughout the body — it means the doctor can consider PN in multiple areas when the main problem is skin quality, based on the product label and the indication approved in Thailand.
| Area | Problem PN may address | When to choose another method or combine treatments |
|---|---|---|
| Under-eye and outer eye corner | Thin, dry skin, fine lines, crepey skin | Deep hollows from bone or fat loss may need filler; visible fat bags may need a surgical assessment |
| Forehead and glabella | Dry skin, fine lines still visible when the face is at rest | Wrinkles dominated by muscle activity usually respond better to toxin |
| Cheeks and mid-face | Pores, uneven texture, tired look | Deep nasolabial folds or sunken cheeks need structural and volume analysis |
| Around the mouth | Fine lines and thin skin around the lips | Lip shape or volume uses filler |
| Jawline and chin | Skin quality and fine lines | Deep jowls or laxity usually need a tightening device |
| Neck | Thin, dry skin, fine wrinkle lines | Significant laxity may need toxin, a device, or surgery |
| Décolletage and back of hands | Dry skin and reduced skin quality | Pigmentation or sun damage may need laser and sun protection |
Assessing the under-eye area by 5 causes
| Cause | Key feature | Approach that may be suitable |
|---|---|---|
| Thin skin and fine lines | Fine lines, dry, crepey skin | PN such as VITARAN may be suitable |
| Deep tear trough | Deep shadow from structure | Suitable filler chosen by an experienced doctor |
| Under-eye bags | Bulging from fat or skin laxity | Assess surgery, a device, or a combined plan |
| Pigmentation | Fixed darkness that does not change with light | Sun protection, topical treatment, or laser |
| Blood vessels and translucency | Purple-tinged darkness from vessels under the skin | Assess the skin and vessels; the effect from PN may be limited |
In a high-risk area such as under the eyes, treatment should be done by a doctor who understands the anatomy and has a plan for managing complications. Using ultrasound may help assess structure or previous products in some cases, but this does not reduce risk to zero.
Comparing VITARAN with the PN, skin booster, and biostimulator groups
เปรียบเทียบ VITARAN กับ Rejuran Profhilo Sculptra Radiesse
| Group / example | Main component | Key difference |
|---|---|---|
| VITARAN | PN | Focuses on PN, not a structure-building filler |
| Rejuran / Plinest / other PN | PN or PDRN depending on formula | Molecule, concentration, viscosity, and brand-specific evidence differ |
| HA skin booster | Non-crosslinked or lightly crosslinked HA | Provides more prominent hydration; not PN |
| Profhilo | Hybrid cooperative HA complexes | HA bioremodeling, not PN |
| Sculptra (PLLA) | Poly-L-lactic acid | Focuses on gradually stimulating collagen and whole-face volume |
| Radiesse (CaHA) | Calcium hydroxylapatite | More of a support and collagen-stimulation role |
| Juvelook (PDLLA + HA) | PDLLA particles combined with HA | Different preparation and stimulation profile |
| PRP / PRF | The patient's own platelets | Autologous; quality depends on preparation and the individual |
One-sentence summary of differences: VITARAN vs Filler — VITARAN focuses on skin quality, filler focuses on filling and structural support · VITARAN vs Botox — VITARAN cares for the skin, Botox reduces muscle activity · VITARAN vs Profhilo — VITARAN is PN, Profhilo is HA bioremodeling · VITARAN vs Sculptra — VITARAN suits fine skin work, Sculptra focuses on stimulating collagen and whole-face volume.
Choosing the right procedure for your problem
| Main concern | Option usually most relevant | Role of VITARAN |
|---|---|---|
| Thin, dry skin, fine lines | PN / skin booster as assessed | The main option for skin quality |
| Deep under-eye hollow or sunken cheeks | HA filler or fixing the structure | May support skin quality but does not replace adding volume |
| Wrinkles when smiling or frowning | Botulinum toxin | Helps the skin but does not stop muscle force |
| Laxity, unclear jawline | Ultrasound / RF / surgery depending on the level | Used to support the skin, not a tightening device |
| Acne scars with fibrosis | Subcision, fractional laser, TCA CROSS | May support recovery but does not cut fibrous bands |
| Wanting more volume or a changed face shape | HA filler, fat grafting, or surgery | Not a face-structuring product |
Treatment steps
- Assess the problem and history — the doctor takes a history of allergies, underlying conditions, medications, supplements, and previous procedures, and checks whether the problem comes from the skin, volume, muscle, fat, pigmentation, or laxity.
- Check the product — verify the formula name, lot number, expiry date, label, and relevant registration status; the box is opened in front of you when possible.
- Plan the technique — the doctor sets the injection points, skin layer, dose, and use of anaesthesia per area; the same package should not be used for every face.
- Perform the procedure — cleanse and inject with an appropriate technique; temporary raised bumps, redness, swelling, bruising, or tenderness may occur.
- Follow up — assess any adverse reactions and adjust the next plan based on the actual response.
How many sessions before you see results? There is no fixed number. One study on the eye area used 3 sessions spaced 2 weeks apart, but a research table should not be copied for every product and every person. In real-world use, a doctor may plan a course of several sessions and then assess how long results last based on age, skin condition, sun exposure, smoking, and skincare.
Side effects and danger signs
| Symptoms that can occur and are usually temporary | Should contact the clinic immediately |
|---|---|
| Raised bumps, redness, swelling, bruising, mild itching, tenderness | Severe or increasing pain, pale or dusky purple skin, or abnormal patterning |
| Tightness or irritation at the injection site | Blurred vision, abnormal vision, sudden drooping eyelid, or severe headache |
| Temporary asymmetry from swelling | Significant swelling, difficulty breathing, hives, or suspected severe allergic reaction |
| Small needle marks | Hot redness, pus, fever, or suspected infection |
| A small lump from the product or inflammation | A firm, chronic lump that is red, painful, or growing |
Aftercare
- Follow the doctor's specific advice, and do not press, massage, or apply compresses yourself unless instructed
- Avoid touching the injection site with unclean hands, avoid cosmetics, and avoid activities that increase heat in the early period per clinic advice
- Avoid alcohol, strenuous exercise, saunas, and heavy sun exposure for the period the doctor sets
- Use sunscreen and a gentle moisturiser
- If there are danger signs, do not wait and watch — contact the clinic or seek emergency care immediately
Frequently asked questions about VITARAN
What is VITARAN?
It is a polynucleotide, or PN, injection programme that supports skin-quality improvement, elasticity, hydration, and fine lines, and must be assessed by a doctor.
Is VITARAN a filler?
It is not a filler for adding volume or shaping the face, although some PN products may be technically classified within the injectable-gel group. Its purpose differs from an HA filler.
Can it be injected under the eyes? Does it help under-eye darkness?
The under-eye area is one where PN research is fairly clear, but thin skin must first be distinguished from deep hollows, fat bags, pigmentation, and blood vessels. It may help when darkness is related to thin skin and skin quality, but if caused by pigmentation, blood vessels, shadow from a hollow, or under-eye bags, the effect may be limited.
Can it be injected all over the face? Can it be used on the neck and back of the hands?
A doctor can consider multiple areas according to the label and skin condition, but the injection points, dose, and skin layer should not be the same everywhere. The neck and back of the hands may be considered when the problem is thin, dry skin with fine lines, but the actual formula's indication should be checked and assessed by a doctor.
Does it hurt? Are there bumps afterward? How many days until results?
There is a sensation from the needle and the product's pressure. The level of sensation varies by area, technique, and anaesthesia used. There may be temporary raised bumps, redness, swelling, or bruising. Some people notice hydration or improved skin texture first, while changes in skin quality are usually gradual and differ between individuals.
How many sessions are needed, and how long do results last?
It is usually planned as a course of several sessions, but the number and spacing depend on the product, skin condition, and the doctor's assessment. Duration depends on age, skin condition, behaviour, sun exposure, smoking, and the treatment plan, so the same number of months should not be guaranteed for everyone.
How is it different from Rejuran and Profhilo?
It is in the same PN group as Rejuran, but the manufacturing source, technology, viscosity, packaging size, formula, and product-specific evidence may differ — you must compare using the actual label. Profhilo uses HA complexes, so its focus and distribution pattern are different.
Can it be combined with Botox, filler, or a tightening device?
It can be combined in some plans because they address different problems, but the sequence and spacing must be set by the doctor.
Who should not have this treatment?
Those who are pregnant or breastfeeding, have an infection at the injection site, have a history of allergy to the components, or have a medical condition that increases risk should avoid it or consult a doctor in detail.
Which is the best choice?
No single product is best for everyone. If the problem is thin skin and fine lines, consider PN. If the problem is prominent dehydration, consider an HA skin booster. If the problem is volume loss, consider a filler or a structure-building biostimulator. If the problem is muscle-related wrinkles, consider toxin. And if the problem is laxity, assess a device or surgery.
Consult a doctor at Orianna Clinic to analyse the cause of your skin's tired appearance before choosing the product that suits you.
Orianna Clinic "Beauty in your own"